By Roger J. Laham, Donald S. Baim
An interdisciplinary panel of pioneers and opinion leaders evaluation the elemental, preclinical, scientific, and developmental pathways to new therapy techniques, comparable to healing angiogenesis and myogenesis. The authors benefit from new organic realizing, novel healing objectives, a number of to be had and well-studied healing ideas, and the mandatory imaging strategies to degree results. Their in-depth discussions conceal the identity of latest healing pursuits and pathways, the research of transcriptional elements, grasp swap molecules, cell-based methods, chemokines, a greater knowing of the results of getting older, endothelial disorder, and hypercholesterolemia in keeping with angiogenic stimuli. Highlights contain exam of drug supply difficulties, results degree, stem treatment, high-risk interventions, improvement pathways, and destiny chances.
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Extra resources for Angiogenesis and direct myocardial revascularization
The homolog of this factor in zebrafish is called gridlock and is a critical mediator of the development of arteries such as the aorta but not of veins (37). The homeobox gene HOX B3 has recently been shown to be involved in facilitating capillary morphogenesis (38). Overexpression of this factor in the chicken chorioallantoic membrane leads to increased capillary vascular density, and antisense oligonucleotides inhibit endothelial tube formation of microvascular endothelial cells cultured on extracellular matrix.
47. Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Mol Cell Biol 1996;16:5091–5106. 36 Oettgen 48. Dube A, Akbarali Y, Sato TN, Libermann TA, Oettgen P. Role of the Ets transcription factors in the regulation of the vascular-specific Tie2 gene [see comments]. Circ Res. 1999;84:1177–1185. 49. Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL.
4. Small, yet easily implemented and maintained Coronary anatomy and innate collateral circulation similar to humans Collateral development in the virtual absence of infarction Consistent, regional abnormalities in left-ventricular (LV) perfusion and function 5. Easily assessed in response to simple interventions Although this optimal model may not always be attainable, models should strive to reflect the “ideal” based on the above criteria and following the basic knowledge of anatomy, physiology, and function (Table 1).
Angiogenesis and direct myocardial revascularization by Roger J. Laham, Donald S. Baim