By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the significant physique of simple technological know-how and scientific information linked to adenomatous polyps of the colon, a lot of it encouraged via the conclusion that the majority colorectal carcinomas appear to come up in such polyps. This publication strives to judge those info, with specific emphasis on their implications for administration of polyp-bearing matters. issues comprehensively explored contain anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic proof for the malignant strength of adenomatous polyps; and detection and administration, with certain consciousness to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Extra resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
This observation provides strong support for the adenoma-carcinoma sequence but unfortunately has not been described in subsequent reports by others. 6. , 1960; Enterline & Arvan, 1967). The latter group demonstrated chromosomal abnormalities consistently in APs: Hyperploidy and structurally abnormal individual chromosomes were more common in the more severely dysplastic or villous tumors. More recently, flow cytometry has been the preferred method of study. Homogenates of nuclei obtained from neoplastic and normal colon are stained and the histograms subsequently generated yield information on DNA ploidy at various stages of the cell cycle.
Goh HS, Jass JR (1986) DNA content and the adenoma-carcinoma sequence in the colorectum. J Clin Pathol 39:387-392. Goldman H, Ming SC, Hickok DF (1970) Nature and significance of hyperplastic polyps of the human colon. Arch Pathol (Chicago) 89:349-354. Goodman ZD, Yardley JH, Milligan FD (1979) Pathogenesis of colonic polyps in multiple juvenile polyposis. Cancer 43:1906-1913. Gottlieb LS, Winawer SJ, Sternberg S, Magrath C, Diaz B, Zauber A, O'Brien M (1984) National Polyp Study (NPS): The diminutive colonic polyp.
1977). In addition to increased expression in neoplasms, CEA also shifts from an apical surface localization in normal colonic epithelium to the entire periphery of cancer cells. , 1987). A shift has also been noted in the location of villin, a cytoskeletal protein normally confined to the microvillous border of colonic epithelial cells. , 1988). Since cytoplasmic localization is also found in fetal colon, at least in the chick, villin can be regarded as an oncofetal antigen, thus resembling CEA.
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features by Robert Lev